文摘
Three new neo-clerodane diterpenoids (1鈥?b>3) along with 12 known compounds (4鈥?b>15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1鈥?b>3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1鈥?b>4, 7, and 10鈥?b>12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 渭M.