Recognition Properties of Cucurbit[7]uril Self-Assembled Monolayers Studied with Force Spectroscopy

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• 作者：Alberto Gomez-Casado ; Pascal Jonkheijm ; Jurriaan Huskens
• 刊名：Langmuir
• 出版年：2011
• 出版时间：September 20, 2011
• 年：2011
• 卷：27
• 期：18
• 页码：11508-11513
• 全文大小：868K
• 年卷期：v.27,no.18(September 20, 2011)
• ISSN：1520-5827

文摘

Specific (host鈥揼uest) and unspecific (substrate鈥揼uest) interactions between self-assembled monolayers of cucurbit[7]uril (CB[7]) on gold (Au) substrates and neutral adamantyl (Ad) guests were resolved by studying these interactions at the single molecule level using dynamic force spectroscopy. The dissociation rate constants of the Ad鈥揂u and the Ad鈥揅B[7] interactions were 0.3 s^鈥? and 0.03 s^鈥?, respectively, indicating that the specific binding is more stable. The probability of observing a specific interaction (40 卤 9%) is similar to the reported surface coverages of CB[7] monolayers on Au substrates. The higher strength and stability of the Ad鈥揅B[7] interactions explains why, although presenting an imperfect coverage, CB[n] monolayers can be used successfully as a platform for surface immobilization.