Systemic Delivery and Biodistribution of Cisplatin in Vivo
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- 作者：Yu-Hsuan Chu ; Martha Sibrian-Vazquez ; Jorge O. Escobedo ; Amanda R. Phillips ; D. Thomas Dickey ; Qi Wang ; Martina Ralle ; Peter S. Steyger ; Robert M. Strongin
- 刊名：Molecular Pharmaceutics
- 出版年：2016
- 出版时间：August 1, 2016
- 年：2016
- 卷：13
- 期：8
- 页码：2677-2682
- 全文大小：446K
- 年卷期：0
- ISSN：1543-8392
文摘
Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin’s off-target effects, a new drug–fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.