Glyconanosomes: Disk-Shaped Nanomaterials for the Water Solubilization and Delivery of Hydrophobic Molecules

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• 作者：Mohyeddin Assali ; Juan-Jos茅 Cid ; Manuel Pern铆a-Leal ; Miguel Mu帽oz-Bravo ; Inmaculada Fern谩ndez ; Ralf E. Wellinger ; Noureddine Khiar
• 刊名：ACS Nano
• 出版年：2013
• 出版时间：March 26, 2013
• 年：2013
• 卷：7
• 期：3
• 页码：2145-2153
• 全文大小：561K
• 年卷期：v.7,no.3(March 26, 2013)
• ISSN：1936-086X

文摘

Herein, we describe the first report on a new class of disk-shaped and quite monodisperse water-soluble nanomaterials that we named glyconanosomes (GNS). GNSs were obtained by sliding out the cylindrical structures formed upon self-organization and photopolymerization of glycolipid 1 on single-walled carbon nanotube (SWCNT) sidewalls. GNSs present a sheltered hydrophobic inner cavity formed by the carbonated tails, surrounded by PEG and lactose moieties. The amphiphilic character of GNSs allows the water solubility of insoluble hydrophobic cargos such as a perylene-bisimide derivative, [60]fullerene, or the anti-carcinogenic drug camptothecin (CPT). GNS/C₆₀ inclusion complexes are able to establish specific interactions between peanut agglutinin (PNA) lectin and the lactose moiety surrounding the complexes, while CPT solubilized by GNS shows higher cytotoxicity toward MCF7-type breast cancer cells than CPT alone. Thus, GNS represents an attractive extension of nanoparticle-based drug delivery systems.

Keywords:

carbon nanotubes; glyconanosomes; camptothecin; drug delivery; noncovalent functionalization; [60]fullerene