Solid-Phase Synthesis of Peptide−Viologen Conjugates

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• 作者：Joseph J. Reczek ; Elisa Rebolini ; Adam R. Urbach
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：March 19, 2010
• 年：2010
• 卷：75
• 期：6
• 页码：2111-2114
• 全文大小：700K
• 年卷期：v.75,no.6(March 19, 2010)
• ISSN：1520-6904

文摘

This paper presents a robust method for the conjugation of viologens to peptides using an amide coupling strategy that is compatible with standard Fmoc solid-phase peptide synthesis. Methodology is presented for monitoring the milligram scale process quantitatively by UV spectroscopy. This chemistry enables the synthesis of a broad range of asymmetric viologens in high yield at room temperature and is compatible with a wide range of functional groups, including amine, guanidinyl, thiol, carboxylic acid, phenol, and indole.