Conversion of Cyclic Ketones to 2,3-Fused Pyrroles and Substituted Indoles

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• 作者：Joshua S. Alford ; Jillian E. Spangler ; Huw M. L. Davies
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：August 14, 2013
• 年：2013
• 卷：135
• 期：32
• 页码：11712-11715
• 全文大小：283K
• 年卷期：v.135,no.32(August 14, 2013)
• ISSN：1520-5126

文摘

A highly effective synthesis of 2,3-fused pyrroles from cyclic ketones has been achieved. The transformation includes a rhodium-catalyzed reaction of 4-alkenyl-1-sulfonyl-1,2,3-triazoles featuring an unusual 4蟺 electrocyclization. The methodology was further extended to the synthesis of indoles using a one-pot reaction starting from 1-ethynylcyclohexenes.