Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

详细信息    查看全文

• 作者：Joshua R. Dunetz ; Javier Magano ; Gerald A. Weisenburger
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：February 19, 2016
• 年：2016
• 卷：20
• 期：2
• 页码：140-177
• 全文大小：2439K
• ISSN：1520-586X

文摘

This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.