Copper-Catalyzed Coupling of 1,1-Dibromo-1-alkenes with Phenols: A General, Modular, and Efficient Synthesis of Ynol Ethers, Bromo Enol Ethers, and Ketene Acetals

详细信息    查看全文

• 作者：K茅vin Jouvin ; Alexandre Bayle ; Fr茅d茅ric Legrand ; Gwilherm Evano
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：March 16, 2012
• 年：2012
• 卷：14
• 期：6
• 页码：1652-1655
• 全文大小：299K
• 年卷期：v.14,no.6(March 16, 2012)
• ISSN：1523-7052

文摘

An efficient and general copper-catalyzed method is reported for the synthesis of phenol-derived 1-bromoenol ethers, ynol ethers, and ketene acetals by chemodivergent copper-catalyzed cross-coupling between readily available 1,1-dibromo-1-alkenes and phenols.