Histidine Based Fluorescence Sensor Detects Hg2+ in Solution, Paper Strips, and in Cells

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• 作者：Joydev Hatai ; Suman Pal ; Gregor P. Jose ; Subhajit Bandyopadhyay
• 刊名：Inorganic Chemistry
• 出版年：2012
• 出版时间：October 1, 2012
• 年：2012
• 卷：51
• 期：19
• 页码：10129-10135
• 全文大小：351K
• 年卷期：v.51,no.19(October 1, 2012)
• ISSN：1520-510X

文摘

A chemosensor having a bipodal thiocarbamate scaffold attached to histidine moieties senses Hg²⁺ with a remarkable selectivity. The binding results in a 50 nm blue shift in the fluorescence spectra and a 19-fold enhancement of the fluorescence quantum yield of the ligand. In addition to the detection of Hg²⁺ visually under UV light in solution, the chemosensor was used for fabrication of paper strips that detected Hg²⁺ in aqueous samples. The sensor was also used for imaging Hg²⁺ in adult zebrafish and in human epithelial carcinoma HeLa S3 cells.