Chiral Brønsted Acid Catalyzed Enantioselective Addition of α-Isocyanoacetamides to Aldehydes

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• 作者：Xiaofei Zeng ; Kehan Ye ; Min Lu ; Pei Juan Chua ; Bin Tan ; Guofu Zhong
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：12
• 期：10
• 页码：2414-2417
• 全文大小：186K
• 年卷期：v.12,no.10(May 21, 2010)
• ISSN：1523-7052

文摘

A clean and highly efficient enantioselective addition of α-isocyanoacetamides to aliphatic aldehydes catalyzed by chiral phosphoric acid in the presence of MS 5 Å in toluene at −40 °C was developed. Excellent yields (85−98%) and good to excellent enantioselectivities (up to >99% ee) were achieved.