I2/O2-Promoted Domino Reactions of Isatins or 3-Hydroxyindolin-2-one Derivatives with Enaminones

详细信息    查看全文

• 作者：Wen-Juan Hao ; Jian-Qiang Wang ; Xiao-Ping Xu ; Shi-Lei Zhang ; Shun-Yi Wang ; Shun-Jun Ji
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：December 20, 2013
• 年：2013
• 卷：78
• 期：24
• 页码：12362-12373
• 全文大小：635K
• 年卷期：v.78,no.24(December 20, 2013)
• ISSN：1520-6904

文摘

I₂-promoted domino reactions of isatins or 3-hydroxyindolin-2-one derivatives with enaminones under O₂ conditions have been established. The reactions of isatins with enaminones afforded functionalized tetracyclic pyrrolo[2,3,4-kl]acridine derivatives in moderate to good yields through domino cyclization and C鈥揌 oxidation. The reactions of 3-hydroxyindolin-2-one derivatives with enaminones proceeded well to give functionalized pyrrolo[2,3,4-kl]acridine derivatives via tandem ring-opening/recyclization/methyl migration sequences with two C鈥揅 bonds cleaved.