Efficient Cycloisomerization of Propargyl Amides by Electrophilic Gold(I) Complexes of KITPHOS Monophosphines: A Comparative Study

详细信息    查看全文

• 作者：Simon Doherty ; Julian G. Knight ; A. Stephen K. Hashmi ; Catherine H. Smyth ; Nicholas A. B. Ward ; Katharine J. Robson ; Sophie Tweedley ; Ross W. Harrington ; William Clegg
• 刊名：Organometallics
• 出版年：2010
• 出版时间：September 27, 2010
• 年：2010
• 卷：29
• 期：18
• 页码：4139-4147
• 全文大小：967K
• 年卷期：v.29,no.18(September 27, 2010)
• ISSN：1520-6041

文摘

Electrophilic gold(I) complexes of diphenyl- and dicyclohexylphosphino-based KITPHOS monophosphines catalyze the 5-exo-dig cycloisomerization of a range of propargyl amides to afford the corresponding alkylidene oxazolines; in all cases catalysts formed from diphenylphosphino-substituted KITPHOS monophosphines outperformed their dicyclohexylphosphino counterparts as well as that based on triphenylphosphine, an indication that the biaryl/biaryl-like framework may be responsible for imparting high catalyst efficiency.