Asymmetric Hydrogenation of Ketones with Ruthenium Complexes of rac- and Enantiopure (S,S)-1,2-Bis((diphenylphosphino)methyl)cyclohexane: A Comparative Study with rac- and
详细信息    查看全文
文摘
Ruthenium(II) complexes of the type trans-[RuCl2{1,2-bis((diphenylphosphino)methyl)cyclohexane}(diamine)] basedon the inexpensive and easy-to-prepare rac- and (S,S)-1,2-bis((diphenylphosphino)methyl)cyclohexane form highly active andenantioselective catalysts for the asymmetric hydrogenation ofa wide range of aryl and heteroaryl ketones, in most cases givingee's that exceed those obtained with their BINAP counterparts.Although precatalysts based on 1,2-bis((diphenylphosphino)methyl)cyclohexane slowly isomerize in solution to afford thethermodynamically favored isomer with a cis arrangement ofchlorides, catalysts generated from both isomers afford similarenantioselectivities.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700