文摘
As an especially unique target for chemical synthesis, diazonamide A has the potential to beconstructed through a plethora of synthetic routes, each attended by different challenges and opportunitiesfor discovery. In this article, we detail our second total synthesis of diazonamide A through a sequenceentirely distinct from that employed in our first campaign, one whose success required the development ofseveral special strategies and tactics. We also disclose our complete studies regarding the chemical biologyof diazonamide A and its structural congeners, and more fully delineate the scope of our protocol forRobinson-Gabriel cyclodehydration using pyridine-buffered POCl3.