Magnetic Silica Nanoparticle Cellular Uptake and Cytotoxicity Regulated by Electrostatic Polyelectrolytes鈥揇NA Loading at Their Surface
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- 作者：Ana B. Davila-Ibanez ; Veronica Salgueirino ; Vicenta Martinez-Zorzano ; Rosalia Mari帽o-Fern谩ndez ; Andres Garc铆a-Lorenzo ; Melodie Maceira-Campos ; Monica Mu帽oz-Ubeda ; Elena Junquera ; Emilio Aicart ; Jose Rivas ; F. Javier Rodriguez-Berrocal ; Jose L. Legido
- 刊名：ACS Nano
- 出版年：2012
- 出版时间：January 24, 2012
- 年：2012
- 卷：6
- 期：1
- 页码：747-759
- 全文大小：801K
- 年卷期：v.6,no.1(January 24, 2012)
- ISSN：1936-086X
文摘
Magnetic silica nanoparticles show great promise for drug delivery. The major advantages correspond to their magnetic nature and ease of biofunctionalization, which favors their ability to interact with cells and tissues. We have prepared magnetic silica nanoparticles with DNA fragments attached on their previously polyelectrolyte-primed surface. The remarkable feature of these materials is the compromise between the positive charges of the polyelectrolytes and the negative charges of the DNA. This dual-agent formulation dramatically changes the overall cytotoxicity and chemical degradation of the nanoparticles, revealing the key role that surface functionalization plays in regulating the mechanisms involved.