Ruthenium-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Aryl and Trifluoromethyl Group Substituted Unsymmetrical Internal Alkynes

详细信息    查看全文

• 作者：Motoi Kawatsura ; Junya Namioka ; Koji Kajita ; Mitsuaki Yamamoto ; Hiroaki Tsuji ; Toshiyuki Itoh
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：June 17, 2011
• 年：2011
• 卷：13
• 期：12
• 页码：3285-3287
• 全文大小：701K
• 年卷期：v.13,no.12(June 17, 2011)
• ISSN：1523-7052

文摘

The regio- and stereoselective addition of carboxylic acids to aryl and trifluoromethyl group substituted unsymmetrical internal alkynes has been accomplished: the Ru₃(CO)₁₂/3PPh₃ catalyst system has effectively catalyzed the reaction to afford the trifluoromethyl group substituted (E)-enol esters with high regio- and stereoselectivities.