Ruthenium-Catalyzed Regioselective [2 + 2 + 2] Cyclotrimerization of Trifluoromethyl Group Substituted Internal Alkynes

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• 作者：Motoi Kawatsura ; Mitsuaki Yamamoto ; Junya Namioka ; Koji Kajita ; Takuya Hirakawa ; Toshiyuki Itoh
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 4, 2011
• 年：2011
• 卷：13
• 期：5
• 页码：1001-1003
• 全文大小：714K
• 年卷期：v.13,no.5(March 4, 2011)
• ISSN：1523-7052

文摘

It found that the Ru₃(CO)₁₂ coordinated with 2-(diphenylphosphino)benzonitrile (2-DPPBN) to effectively catalyze the [2 + 2 + 2] cyclotrimerization of the trifluoromethyl group substituted internal alkynes in high yields with up to >98% regioselectivity. Isolation of a ruthenacyclopentadiene was successful and confirmed that the complex is a reaction intermediate.