Enantioselective Liquid鈥揝olid Extraction (ELSE)鈥擜n Unexplored, Fast, and Precise Analytical Method

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• 作者：Filip Ulatowski ; Paulina Hamankiewicz ; Janusz Jurczak
• 刊名：ACS Combinatorial Science
• 出版年：2015
• 出版时间：September 14, 2015
• 年：2015
• 卷：17
• 期：9
• 页码：488-492
• 全文大小：281K
• ISSN：2156-8944

文摘

A novel method of evaluating the enantioselectivity of chiral receptors is investigated. It involves extraction of an ionic guest in racemic form from an ion-exchange resin to the organic solvent, where it is bound by a chiral receptor. The enantioselectivity of the examined receptor is determined simply by measuring the enantiomeric excess of the extracted guest. We show that the concept is viable for neutral receptors binding chiral organic anions extracted into acetonitile. This method was determined to be more accurate and far less time-consuming than the classical titrations. Multiple racemic guests can be applied to a resin in a single experiment, giving the method a very high throughput.