Cytotoxic Withanolides from Tubocapsicum anomalum
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- 作者：Pei-Wen Hsieh ; Zih-You Huang ; Jyun-Hong Chen ; Fang-Rong Chang ; Ching-Chung Wu ; Yu-Liang Yang ; Michael Y. Chiang ; Ming-Hon Yen ; Shu-Li Chen ; Hsin-Fu Yen ; Tilo Lü ; bken ; Wen-Chun Hung ; and ; Yang-Chang
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：May 2007
- 年：2007
- 卷：70
- 期：5
- 页码：747 - 753
- 全文大小：115K
- 年卷期：v.70,no.5(May 2007)
- ISSN：1520-6025
文摘
Fifteen new withanolides (1-8, 11-17) and two known withanolides, withanolide D (9) and 17
-hydroxywithanolideD (10), were isolated from the stems, roots, and leaves of Tubocapsicum anomalum using bioassay-directed fractionation.The structures were determined by spectroscopic and chemical methods, and the absolute configurations were establishedby CD analysis and by the Mosher ester method. The structure of 1 and 3 were further confirmed by X-ray crystallographicanalysis. Compounds 1, 4-6, 8-10, and 13 showed significant cytotoxic activity against Hep G2, Hep 3B, A-549,MDA-MB-231, MCF-7, and MRC-5 cell lines.
-hydroxywithanolideD (10), were isolated from the stems, roots, and leaves of Tubocapsicum anomalum using bioassay-directed fractionation.The structures were determined by spectroscopic and chemical methods, and the absolute configurations were establishedby CD analysis and by the Mosher ester method. The structure of 1 and 3 were further confirmed by X-ray crystallographicanalysis. Compounds 1, 4-6, 8-10, and 13 showed significant cytotoxic activity against Hep G2, Hep 3B, A-549,MDA-MB-231, MCF-7, and MRC-5 cell lines.