Titanocene-Catalyzed Cyclocarbonylation of o-Allyl Aryl Ketones to -Butyrolactones
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- 作者：Natasha M. Kablaoui ; Frederick A. Hicks ; and Stephen L. Buchwald
- 刊名：Journal of the American Chemical Society
- 出版年：1997
- 出版时间：May 14, 1997
- 年：1997
- 卷：119
- 期：19
- 页码：4424 - 4431
- 全文大小：351K
- 年卷期：v.119,no.19(May 14, 1997)
- ISSN：1520-5126
文摘
A method for the transformation of o-allyl aryl ketonesto 
-butyrolactones using a catalytic amount ofCp2Ti(PMe3)2 orCp2Ti(CO)2 is described. Thiscatalytic "hetero Pauson-Khand"-type process proceedsvia thecarbonylation of an oxatitanacycle followed by thermally-inducedreductive elimination to form a -butyrolactoneand to regenerate the catalyst. We have investigated the scope andlimitations of this catalytic methodology. Ourresults are consistent with the view that the key step in thiscatalytic cycle is formation of a charge transfer complexor involves reversible electron transfer between the catalyst and thesubstrate.
-butyrolactones using a catalytic amount ofCp2Ti(PMe3)2 orCp2Ti(CO)2 is described. Thiscatalytic "hetero Pauson-Khand"-type process proceedsvia thecarbonylation of an oxatitanacycle followed by thermally-inducedreductive elimination to form a -butyrolactoneand to regenerate the catalyst. We have investigated the scope andlimitations of this catalytic methodology. Ourresults are consistent with the view that the key step in thiscatalytic cycle is formation of a charge transfer complexor involves reversible electron transfer between the catalyst and thesubstrate.