A Simple and Convenient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature

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• 作者：He Huang ; Hualiang Jiang ; Kaixian Chen ; Hong Liu
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：August 7, 2009
• 年：2009
• 卷：74
• 期：15
• 页码：5476-5480
• 全文大小：772K
• 年卷期：v.74,no.15(August 7, 2009)
• ISSN：1520-6904

文摘

We developed a simple and convenient copper-catalyzed method for the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation. The efficiency of this system allowed the reactions to be carried out at room temperature.