Regioselective Rapid Synthesis of Fully Substituted 1,2,3-Triazoles Mediated by Propargyl Cations

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• 作者：Huan Zhang ; Hiroki Tanimoto ; Tsumoru Morimoto ; Yasuhiro Nishiyama ; Kiyomi Kakiuchi
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 18, 2013
• 年：2013
• 卷：15
• 期：20
• 页码：5222-5225
• 全文大小：316K
• 年卷期：v.15,no.20(October 18, 2013)
• ISSN：1523-7052

文摘

Regioselective rapid triazole syntheses at low temperature are described. Organic azides and propargyl cations generated by acids gave fully substituted 1H-1,2,3-triazoles. Most reactions could be performed in 5 min at not only rt but also 鈭?0 掳C. Both terminal and internal alkynes were acceptable, and the sterically bulky substituents could afford the products smoothly. Various types of three-component coupling reactions were demonstrated, and the presence of allenylaminodiazonium intermediates was indicated.