Gemini Imidazolium Surfactants: Synthesis and Their Biophysiochemical Study

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• 作者：Raman Kamboj ; Sukhprit Singh ; Avinash Bhadani ; Hardeep Kataria ; Gurcharan Kaur
• 刊名：Langmuir
• 出版年：2012
• 出版时间：August 21, 2012
• 年：2012
• 卷：28
• 期：33
• 页码：11969-11978
• 全文大小：499K
• 年卷期：v.28,no.33(August 21, 2012)
• ISSN：1520-5827

文摘

New gemini imidazolium surfactants 9鈥?b>13 have been synthesized by a regioselective epoxy ring-opening reaction under solvent-free conditions. The surface properties of these new gemini surfactants were evaluated by surface tension and conductivity measurements. These surfactants have been found to have low critical micelle concentration (cmc) values as compared to other categories of gemini cationic surfactants and also showed the tendency to form premicellar aggregates in solution at sufficiently low concentration below their cmc values. The thermal degradation of these surfactants was determined by thermograviometry analysis (TGA). These new cationic surfactants have a good DNA binding capability as determined by agarose gel electrophoresis and ethidium bromide exclusion experiments. They have also been found to have low cytotoxicity by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on the C6 glioma cell line.