Bimorpholine-Mediated Enantioselective Intramolecular and Intermolecular Aldol Condensation

详细信息    查看全文

• 作者：Tõ ; nis Kanger ; Kadri Kriis ; Marju Laars ; Tiiu Kailas ; Aleksander-Mati Mü ; ü ; risepp ; Tõ ; nis Pehk ; Margus Lopp
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：July 6, 2007
• 年：2007
• 卷：72
• 期：14
• 页码：5168 - 5173
• 全文大小：115K
• 年卷期：v.72,no.14(July 6, 2007)
• ISSN：1520-6904

文摘

Monosalts of N-substituted bimorpholine derivatives are efficient organocatalysts in intramolecular andintermolecular aldol reactions. The properties of the catalysts can be tuned either by the selection of anappropriate acid for the salt formation or by the change of a substituent at the nitrogen atom. In aldolcondensation, i-Pr-substituted bimorpholine is the most stereoselective catalyst affording products in highyield with enantioselectivities up to 95% ee.