CaCl2, Bisoxazoline, and Malonate: A Protocol for an Asymmetric Michael Reaction
详细信息 查看全文
- 作者：Kristin Lippur ; Sandra Kaabel ; Ivar J盲rving ; Kari Rissanen ; T玫nis Kanger
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：June 19, 2015
- 年：2015
- 卷：80
- 期：12
- 页码：6336-6341
- 全文大小：371K
- ISSN：1520-6904
文摘
A mild protocol for the asymmetric Michael addition of dimethyl malonate to various 伪,尾-unsaturated carbonyl compounds was developed. The salient feature of this methodology is that a cheap and environmentally friendly Lewis acid, CaCl2, was used as a catalyst. An aminoindanol- and pyridine-derived ligand provided in the presence of CaCl2 Michael adducts in moderate to high enantioselectivities. The scope of the reaction was demonstrated.