Development of Multigram Scale Synthesis of Trifluoromethylthiolating Reagent: (bpy)CuSCF3
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- 作者：Yunxiao Zhang ; Kangji Gan ; Zhiqiang Weng
- 刊名：Organic Process Research & Development
- 出版年：2016
- 出版时间：April 15, 2016
- 年：2016
- 卷：20
- 期：4
- 页码：799-802
- 全文大小：247K
- 年卷期：0
- ISSN：1520-586X
文摘
A practical and reproducible procedure for the efficient preparation of (bpy)CuSCF3 (1), a copper reagent for trifluoromethylthiolation reaction, is reported. All reaction parameters were optimized, and reagent 1 was synthesized in 26 g scale. Finally, the utility of the reagent 1 was highlighted in the synthesis of a Toltrazuril intermediate on a preparative scale.