Curtius-like Rearrangement of an Iron–Nitrenoid Complex and Application in Biomimetic Synthesis of Bisindolylmethanes

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• 作者：Dashan Li ; Ting Wu ; Kangjiang Liang ; Chengfeng Xia
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2228-2231
• 全文大小：344K
• 年卷期：0
• ISSN：1523-7052

文摘

A Curtius-like rearrangement of hydroxamates to isocyanates was discovered. This reaction was initiated from an iron(II)–nitrenoid complex, which was generated by the iron(II)-catalyzed cleavage of N–O bonds of functionalized hydroxamates. To demonstrate the efficiency of this new Curtius-like rearrangement in synthetic chemistry, a biomimetic strategy for the one-pot preparation of bisindolylmethanes was developed.