One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles

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• 作者：Amrei Deutsch ; Christoph Jessen ; Carl Deutsch ; Konstantin Karaghiosoff ; Anja Hoffmann-Röder
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：18
• 期：14
• 页码：3474-3477
• 全文大小：336K
• 年卷期：0
• ISSN：1523-7052

文摘

An operationally simple one-pot reaction for the preparation of a novel class of racemic trifluoromethylated 2,3-dihydro-1H-imidazoles derived from electron-poor N,O-acetals and aryl Grignard reagents is described. In addition, access to highly functionalized 2-trifluoromethyl-2,3-dihydro-1H-imidazoles was accomplished by reaction of N-aryl hemiaminal ethers and N-aryl trifluoroethylamines in the presence of an excess of n-butyllithium.