Bioinformatics Processing of Protein and Transcript Profiles of Normal and Transformed Cell Lines Indicates Functional Impairment of Transcriptional Regulators in Buccal Carcinoma

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• 作者：Claudia A. Staab ; Rebecca Ceder ; Theres Jä ; gerbrink ; Jan-Anders Nilsson ; Karin Roberg ; Hans J&ouml ; rnvall ; Jan-Olov H&ouml ; &ouml ; g ; Roland C. Grafstr&ouml ; m
• 刊名：Journal of Proteome Research
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：6
• 期：9
• 页码：3705 - 3717
• 全文大小：685K
• 年卷期：v.6,no.9(September 2007)
• ISSN：1535-3907

文摘

Normal and two transformed buccal keratinocyte lines were cultured under a standardized conditionto explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein levels.An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-scale transcript data to low-abundance transcriptional regulators. The analysis identified previouslyproposed and suggested novel protein biomarkers, gene ontology categories, molecular networks, andfunctionally impaired key regulator genes for buccal/oral carcinoma.