Nocardichelins A and B, Siderophores from Nocardia Strain Acta 3026
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- 作者：Kathrin Schneider ; Ilona Rose ; Sabaratnam Vikineswary ; Amanda L. Jones ; Michael Goodfellow ; Graeme Nicholson ; Winfried Beil ; Roderich D. Sü ; ssmuth ; Hans-Peter Fiedler
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：June 2007
- 年：2007
- 卷：70
- 期：6
- 页码：932 - 935
- 全文大小：103K
- 年卷期：v.70,no.6(June 2007)
- ISSN：1520-6025
文摘
An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genusNocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compoundsstrongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma withGI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performedby mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combinethe structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores(desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation,was positive, confirming the role as a siderophore.