Salicylic Acid (SA) Bioaccessibility from SA-Based Poly(anhydride-ester)

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• 作者：Michael A. Rogers ; Yim-Fan Yan ; Karen Ben-Elazar ; Yaqi Lan ; Jonathan Faig ; Kervin Smith ; Kathryn E. Uhrich
• 刊名：Biomacromolecules
• 出版年：2014
• 出版时间：September 8, 2014
• 年：2014
• 卷：15
• 期：9
• 页码：3406-3411
• 全文大小：341K
• ISSN：1526-4602

文摘

The bioaccessibility of salicylic acid (SA) can be effectively modified by incorporating the pharmacological compound directly into polymers such as poly(anhydride-esters). After simulated digestion conditions, the bioaccessibility of SA was observed to be statistically different (p < 0.0001) in each sample: 55.5 卤 2.0% for free SA, 31.2 卤 2.4% the SA-diglycolic acid polymer precursor (SADG), and 21.2 卤 3.1% for SADG-P (polymer). The release rates followed a zero-order release rate that was dependent on several factors, including (1) solubilization rate, (2) macroscopic erosion of the powdered polymer, (3) hydrolytic cleavage of the anhydride bonds, and (4) subsequent hydrolysis of the polymer precursor (SADG) to SA and diglycolic acid.