Bioassay-Guided Isolation of Xanthones and Polycyclic Prenylated Acylphloroglucinols from Garcinia oblongifolia
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- 作者：Sheng-Xiong Huang ; Chao Feng ; Yan Zhou ; Gang Xu ; Quan-Bin Han ; Chun-Feng Qiao ; Donald C. Chang ; Kathy Qian Luo ; Hong-Xi Xu
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：January 23, 2009
- 年：2009
- 卷：72
- 期：1
- 页码：130-135
- 全文大小：161K
- 年卷期：v.72,no.1(January 23, 2009)
- ISSN：1520-6025
文摘
Bioassay-guided fractionation of the acetone extract of the bark of Garcinia oblongifolia has resulted in the isolation of three new xanthones, oblongixanthones A−C (1−3), three new polyprenylated benzoylphloroglucinols, oblongifolins E−G (4−6), and 12 known compounds. Oblongifolins I (5) and J (6) are the first natural products that have similar structural features to those of two known oxidation products of garcinol. The structures of the new compounds 1−6 were characterized by spectroscopic data interpretation. All isolates were assayed for their apoptosis-inducing effects against HeLa-C3 cells. Oblongifolin C (16) was found to be the most potent apoptotic inducer of the compounds evaluated.