Effects of Nanoparticle Morphology and Acyl Chain Length on Spontaneous Lipid Transfer Rates

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• 作者：Yan Xia ; Ming Li ; Kamil Charubin ; Ying Liu ; Frederick A. Heberle ; John Katsaras ; Benxin Jing ; Yingxi Zhu ; Mu-Ping Nieh
• 刊名：Langmuir
• 出版年：2015
• 出版时间：December 1, 2015
• 年：2015
• 卷：31
• 期：47
• 页码：12920-12928
• 全文大小：550K
• ISSN：1520-5827

文摘

We report on studies of lipid transfer rates between different morphology nanoparticles and lipids with different length acyl chains. The lipid transfer rate of dimyristoylphosphatidylcholine (di-C₁₄, DMPC) in discoidal 鈥渂icelles鈥?(0.156 h^鈥?) is 2 orders of magnitude greater than that of DMPC vesicles (ULVs) (1.1 脳 10^鈥? h^鈥?). For both bicellar and ULV morphologies, increasing the acyl chain length by two carbons [going from di-C₁₄ DMPC to di-C₁₆, dipalmitoylphosphatidylcholine (DPPC)] causes lipid transfer rates to decrease by more than 2 orders of magnitude. Results from small angle neutron scattering (SANS), differential scanning calorimetry (DSC), and fluorescence correlation spectroscopy (FCS) are in good agreement. The present studies highlight the importance of lipid dynamic processes taking place in different morphology biomimetic membranes.