Tumour Metabolomics in Animal Models of Human Cancer

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• 作者：Julian L. Griffin ; Risto A. Kauppinen
• 刊名：Journal of Proteome Research
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：6
• 期：2
• 页码：498 - 505
• 全文大小：233K
• 年卷期：v.6,no.2(February 2007)
• ISSN：1535-3907

文摘

Multinuclear Nuclear Magnetic Resonance Spectroscopy (MRS) and mass spectrometry (MS) are thekey analytical techniques used in an increasing manner to explore tumor metabolite profiles. Recentwork has revealed that metabolite profiles in various tumor preparations (i.e., cultured cells, tissuespecimens, and tumors in vivo) show strong correlations with tumor type, proliferation, metabolicactivity, and cell death. These data are regarded as highly promising for tumor diagnosis as well asassessment of prognosis and treatment response in a clinical setting. In this pursuit, animal models ofhuman cancer have played a central role. In this short account, we review the potentials of MRS andMS techniques for animal tumor metabolomic work, as well as highlight some interesting applicationsof these techniques for various animal tumor types.