Synthesis of Natural Cyclopentapeptides Isolated from Dianthus chinensis
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- 作者：Shengping Zhang ; Zaid Amso ; Luis M. De Leon Rodriguez ; Harveen Kaur ; Margaret A. Brimble
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：July 22, 2016
- 年：2016
- 卷：79
- 期：7
- 页码：1769-1774
- 全文大小：289K
- 年卷期：0
- ISSN：1520-6025
文摘
The first syntheses of the naturally occurring cyclic peptides dianthin I (1), pseudostellarin A (2), and heterophyllin J (3) are described. The linear protected peptide precursors were prepared efficiently via Fmoc-solid-phase synthesis and subsequently cyclized in solution under dilute conditions. The structures of the synthetic cyclopentapeptides were confirmed by NMR spectroscopy and mass spectrometry and were in agreement with the literature data reported for the natural products.