Traceless Synthesis of Hydantoin Fused Tetrahydro-β-carboline on Ionic Liquid Support in Green Media

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• 作者：Barnali Maiti ; Kaushik Chanda ; Chung-Ming Sun
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：November 5, 2009
• 年：2009
• 卷：11
• 期：21
• 页码：4826-4829
• 全文大小：224K
• 年卷期：v.11,no.21(November 5, 2009)
• ISSN：1523-7052

文摘

A novel ionic liquid (IL) supported, green synthetic protocol has been developed toward the synthesis of oxo and thio hydantoin analogues tethered with tetrahydro-β-carboline by the use of focused microwave irradiation. IL-bound tryptophan underwent a Pictet−Spengler reaction with various carbonyl compounds to generate the IL- immobilized tetrahydro-β-carbolines in aqueous isopropanol media. Subsequent reaction of substituted tetrahydro-β-carboline derivatives with various isocyanates and isothiocyanate provided a three-dimensional combinatorial library in a traceless fashion.