Asymmetric Intermolecular Conjugate Addition of Amino Acid Derivatives via Memory of Chirality: Total Synthesis of Manzacidin A

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• 作者：Tomoyuki Yoshimura ; Tomohiko Kinoshita ; Hiroyasu Yoshioka ; Takeo Kawabata
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：February 15, 2013
• 年：2013
• 卷：15
• 期：4
• 页码：864-867
• 全文大小：260K
• 年卷期：v.15,no.4(February 15, 2013)
• ISSN：1523-7052

文摘

Asymmetric intermolecular conjugate addition of 伪-amino acid derivatives with 4 via memory of chirality has been developed. The reactions proceeded in up to 98% ee with retention of configuration at the newly formed tetrasubstituted carbon center when R = Me. The product (R = Me) was transformed into manzacidin A.