Double-Stranded RNA Homopolymer Poly(rC)·Poly(rG) for a New pH-Sensitive Drug Carrier

详细信息    查看全文

• 作者：Shoichiro Asayama ; Ai Ogawa ; Hiroyoshi Kawakami ; Shoji Nagaoka
• 刊名：Molecular Pharmaceutics
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：5
• 期：1
• 页码：162 - 164
• 全文大小：193K
• 年卷期：v.5,no.1(February 2008)
• ISSN：1543-8392

文摘

Double-stranded RNA homopolymer poly(rC)·poly(rG) has been used as a new pH-sensitive drug carrier. The poly(rC)·poly(rG) had proton buffering capacity around pH 6, owing to protonation of cytosine, as determined by acid–base titration. By circular dichroism measurement, the protonation caused conformational change of the RNA. The poly(rC)·poly(rG) and doxorubicin (Dox), as an anticancer drug, formed the complexes which released the drugs at endosomal pH. The resulting complex exhibited higher anticancer activity than the Dox alone. These results result suggest that the poly(rC)·poly(rG) is a promising biopolymer for a new class of pH-sensitive drug carriers.