Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8–C29 Fragment

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• 作者：Yuki Kawashima ; Atsushi Toyoshima ; Haruhiko Fuwa ; Makoto Sasaki
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2232-2235
• 全文大小：413K
• 年卷期：0
• ISSN：1523-7052

文摘

A synthesis of the C8–C29 fragment of amphidinolide N, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been achieved. The key features of the synthesis involve a convergent union of the C9–C15 and C16–C29 fragments by Steglich esterification and the construction of a pyran unit through a Tebbe methylenation/ring-closing metathesis sequence.