Novel and Efficient Chromium(II)-Mediated Desulfonylation of 伪-Sulfonyl Ketone
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- 作者：Kazato Inanaga ; Takashi Fukuyama ; Manabu Kubota ; Yuki Komatsu ; Hiroyuki Chiba ; Akio Kayano ; Katsuya Tagami
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：June 19, 2015
- 年：2015
- 卷：17
- 期：12
- 页码：3158-3161
- 全文大小：285K
- ISSN：1523-7052
文摘
A novel and efficient method for the Cr(II)-mediated desulfonylation of 伪-sulfonyl ketone by a Cr鈥搇igand鈥揗n system has been developed during the course of process research on Halaven (eribulin mesylate). This reaction is dramatically accelerated in the presence of an appropriate bipyridyl-type ligand. This system is applicable to reduction of 伪-sulfur-substituted ketones. In addition, a Cr鈥揅p2ZrCl2鈥揗n catalytic system is also applicable to desulfonylation of 伪-sulfonyl ketone.