Peptide-Catalyzed Diastereo- and Enantioselective Cyclopropanation of Aromatic 伪,尾-Unsaturated Aldehydes

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• 作者：Kengo Akagawa ; Shota Takigawa ; Iman Sho Nagamine ; Ryota Umezawa ; Kazuaki Kudo
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 4, 2013
• 年：2013
• 卷：15
• 期：19
• 页码：4964-4967
• 全文大小：289K
• 年卷期：v.15,no.19(October 4, 2013)
• ISSN：1523-7052

文摘

Highly diastereo- and enantioselective cyclopropanation of aromatic 伪,尾-unsaturated aldehydes was achieved using a resin-supported peptide catalyst under aqueous conditions. In the peptide sequence, the residue possessing an oxygen atom with the appropriate length of the side chain was essential for attaining good diastereoselectivity.