Inhibition of Photodegradation of Highly Dispersed Folic Acid Nanoparticles by the Antioxidant Effect of Transglycosylated Rutin

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• 作者：Kazunori Kadota ; Kumi Semba ; Ryosuke Shakudo ; Hideyuki Sato ; Yuto Deki ; Yoshiyuki Shirakawa ; Yuichi Tozuka
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：April 20, 2016
• 年：2016
• 卷：64
• 期：15
• 页码：3062-3069
• 全文大小：518K
• 年卷期：0
• ISSN：1520-5118

文摘

We developed highly dispersible and photostable nanoparticles of vitamin, folic acid (FA). FA was wet bead milled with milling and dispersing adjuvants and transglycosylated compounds such as α-glucosyl hesperidin (Hesperidin-G) and rutin (Rutin-G), which solubilized FA. The milled slurries of FA particles with transglycosylated compounds consisted of nanosized particles with a median diameter of <100 nm. The lyophilized formulations of these slurries retained their nanometer size after resuspension in water with no aggregation. The apparent solubility of FA in these formulations was 100-fold higher than that of untreated FA. The solubilizing effect of Rutin-G may affect the particle size reduction and dispersibility of FA. The photostability results showed that the strong antioxidant activity of Rutin-G substantially increased the photostability of FA solution. On the basis of these results, bead milling of FA with Rutin-G is a promising technique for developing highly dispersible, photostable nanoparticle FA formulations.