Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from Stellera chamaejasme

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• 作者：Yoshihisa Asada ; Aya Sukemori ; Takashi Watanabe ; Kuber J. Malla ; Takafumi Yoshikawa ; Wei Li ; Xinzhu Kuang ; Kazuo Koike ; Chin-Ho Chen ; Toshiyuki Akiyama ; Keduo Qian ; Kyoko Nakagawa-Goto ; Susan L. Morris-Natschke ; Yan Lu ; Kuo-Hsiung Lee
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：May 24, 2013
• 年：2013
• 卷：76
• 期：5
• 页码：852-857
• 全文大小：235K
• 年卷期：v.76,no.5(May 24, 2013)
• ISSN：1520-6025

文摘

Five novel tigliane-type diterpenes, stelleracins A鈥揈 (3鈥?b>7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3鈥?b>5 showed potent anti-HIV activity (EC₉₀ 0.00056鈥?.0068 渭M) and relatively low or no cytotoxicity (IC₅₀ 4.4鈥?7.2 渭M). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.