Micellization and Drug Solubilization in Aqueous Solutions of a Diblock Copolymer of Ethylene Oxide and Phenyl Glycidyl Ether

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• 作者：Pablo Taboada ; Gemma Velasquez ; Silvia Barbosa ; Zhuo Yang ; S. Keith Nixon ; Zhengyuan Zhou ; Frank Heatley ; Marianne Ashford ; Victor Mosquera ; David Attwood ; Colin Booth
• 刊名：Langmuir
• 出版年：2006
• 出版时间：August 29, 2006
• 年：2006
• 卷：22
• 期：18
• 页码：7465 - 7470
• 全文大小：78K
• 年卷期：v.22,no.18(August 29, 2006)
• ISSN：1520-5827

文摘

The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorlysoluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblockcopolymer G₅E₆₇ (G = phenyl glycidyl ether, OCH₂CH(CH₂OC₆H₅); E = oxyethylene, OCH₂CH₂; subscripts denotenumber-average block lengths in repeat units). The association properties in aqueous solution over the range 20-50s/entities/deg.gif">C were investigated by surface tensiometry and light scattering, yielding values of the cmc, hydrodynamic radius,and association number; gel boundaries in concentrated micellar solution were investigated by tube inversion. Thesolubilization capacity of G₅E₆₇ for the poorly water-soluble drug griseofulvin was higher than that of a triblock EGEcopolymer of longer G block length and considerably higher than that achieved with poloxamers (E_mP_nE_m, P =oxypropylene).