The aim of thi
s study wa
s to define a block copolymer micellar
sy
stem with a high
solubilization capacity for poorly
soluble aromatic drug
s. Ethylene oxide and phenyl glycidyl ether were
sequentially polymerized to form the diblockcopolymer G
5E
67 (G = phenyl glycidyl ether, OCH
2CH(CH
2OC
6H
5); E = oxyethylene, OCH
2CH
2;
sub
script
s denotenumber-average block length
s in repeat unit
s). The a
ssociation propertie
s in aqueou
s solution over the range 20-50

s/entitie
s/deg.gif">C were inve
stigated by
surface ten
siometry and light
scattering, yielding value
s of the cmc, hydrodynamic radiu
s,and a
ssociation number; gel boundarie
s in concentrated micellar
solution were inve
stigated by tube inver
sion. The
solubilization capacity of G
5E
67 for the poorly water-
soluble drug gri
seofulvin wa
s higher than that of a triblock EGEcopolymer of longer G block length and con
siderably higher than that achieved with poloxamer
s (E
mP
nE
m, P =oxypropylene).