High Strength Bimodal Amphiphilic Conetworks for Immunoisolation Membranes: Synthesis, Characterization, and Properties

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• 作者：Gustavo Guzman ; Turgut Nugay ; Isil Nugay ; Nihan Nugay ; Joseph Kennedy ; Mukerrem Cakmak
• 刊名：Macromolecules
• 出版年：2015
• 出版时间：September 8, 2015
• 年：2015
• 卷：48
• 期：17
• 页码：6251-6262
• 全文大小：847K
• ISSN：1520-5835

文摘

A strategy for the synthesis of new cross-linkable bimodal amphiphilic grafts (bAPGs) was developed. These grafts are of hydrophilic PDMAAm backbones carrying low (M_n 鈭?17鈥?00 g/mol) and high (M_n 鈭?117鈥?00 g/mol) molecular weight hydrophobic PDMS branches, each branch carrying a vinylsilyl end-group. The bAPGs were cross-linked by Karstedt catalyst to bimodal amphiphilic conetworks (bAPCNs) by the use of polyhydrosiloxane-co-PDMS as the cross-linker. Membranes prepared from bAPCNs exhibit mechanical properties surprisingly superior to earlier APCNs prepared with APGs with monomodal low molecular weight branches. Membrane bimodality controls surface morphology and topography by means of elastic wrinkling instability during film formation. Semipermeable bAPCN membranes with precisely controlled nanochannel dimensions were prepared so as to allow rapid insulin diffusion and prevent passage of IgG. bAPCN membranes were designed for immunoprotection of live pancreatic islets and are thus key components for a bioartificial pancreas.