Cytotoxic Polyisoprenyl Benzophenonoids from Garcinia subelliptica
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- 作者：Li-Jie Zhang ; Chun-Tang Chiou ; Jing-Jy Cheng ; Hui-Chi Huang ; Li-Ming Yang Kuo ; Chia-Chin Liao ; Kenneth F. Bastow ; Kuo-Hsiung Lee ; Yao-Haur Kuo
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：April 23, 2010
- 年：2010
- 卷：73
- 期：4
- 页码：557-562
- 全文大小：203K
- 年卷期：v.73,no.4(April 23, 2010)
- ISSN：1520-6025
文摘
Six new polyisoprenyl benzophenonoids, (±)-garcinialiptone A (1, 2), garcinialiptone B (3), (−)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 1−6 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 1−9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).