A Convergent Synthesis of the Tricyclic Core of the Dictyosphaeric Acids

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• 作者：Christopher W. Barfoot ; Alan R. Burns ; Michael G. Edwards ; Martin N. Kenworthy ; Mahmood Ahmed ; Stephen E. Shanahan ; Richard J. K. Taylor
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：January 17, 2008
• 年：2008
• 卷：10
• 期：2
• 页码：353 - 356
• 全文大小：99K
• 年卷期：v.10,no.2(January 17, 2008)
• ISSN：1523-7052

文摘

The first synthetic route to the tricyclic core of the dictyosphaeric acids has been established starting from readily available (S)-(-)-4-(tert-butyldimethylsilyloxy)cyclohexenone and involving 9 steps, including a ring-closing metathesis to produce a 13-membered macrolactone, anda doubly tethered intramolecular Michael addition.