Discrete-Time Signal Processing with DNA
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- 作者：Hua Jiang ; Sayed Ahmad Salehi ; Marc D. Riedel ; Keshab K. Parhi
- 刊名：ACS Synthetic Biology
- 出版年：2013
- 出版时间：May 17, 2013
- 年：2013
- 卷：2
- 期：5
- 页码：245-254
- 全文大小：586K
- 年卷期：v.2,no.5(May 17, 2013)
- ISSN：2161-5063
文摘
We present a methodology for implementing discrete-time signal processing operations, such as filtering, with molecular reactions. The reactions produce time-varying output quantities of molecules as a function of time-varying input quantities according to a functional specification. This computation is robust and independent of the reaction rates, provided that the rate constants fall within coarse categories. We describe two approaches: one entails synchronization with a clock signal, implemented through sustained chemical oscillations; the other is 鈥渟elf-timed鈥?or asynchronous. We illustrate the methodology by synthesizing a simple moving-average filter, a biquad filter, and a Fast Fourier Transform (FFT). Abstract molecular reactions for these filters and transforms are translated into DNA strand displacement reactions. The computation is validated through mass-action simulations of the DNA kinetics. Although a proof of concept for the time being, molecular filters and transforms have potential applications in fields such as biochemical sensing and drug delivery.