Volumetric and Viscosity Studies of Aqueous Solutions of the Potassium Salt of Penicillin-G at Different Temperatures and at Ambient Pressure

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• 作者：Dilip H. Dagade ; Sanjay D. Patil ; Kesharsingh J. Patil
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：52
• 期：6
• 页码：2177 - 2181
• 全文大小：65K
• 年卷期：v.52,no.6(November 2007)
• ISSN：1520-5134

文摘

Density and viscosity measurements are reported for aqueous solutions of the potassium salt of penicillin-G atdifferent temperatures (293.15 K to 308.15 K) and at ambient pressure. The density data are used to obtainapparent molar volumes of the potassium salt of penicillin-G (PGK). Also, the coefficient of thermal expansionand apparent molar expansivity data has been obtained using the density data at different temperatures. Therelative viscosities (_r) and the viscosity A, B, and D coefficients in the Jones-Dole equation _r = 1 + Ac^1/2 +Bc + Dc², with c = concentration of the potassium salt of penicillin-G in aqueous solutions (0.005 mol·dm^-3 to0.12 mol·dm^-3), have been determined. The values of the B and D coefficients were found to be high comparedto simple 1:1 electrolytes. The values of the A coefficient do not show any trend as a function of temperature;however, the B coefficient decreases with an increase in temperature. The results are explained in terms ofhydrophobic hydration of the anion and hydrophobic interactions between penicillin-G molecules in the premicellarregion.