Synthesis of 伪-Hydroxyacetophenones

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• 作者：Mark McLaughlin ; Kevin M. Belyk ; Gang Qian ; Robert A. Reamer ; Cheng-yi Chen
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：June 1, 2012
• 年：2012
• 卷：77
• 期：11
• 页码：5144-5148
• 全文大小：253K
• 年卷期：v.77,no.11(June 1, 2012)
• ISSN：1520-6904

文摘

A general method for the preparation of 伪-hydroxyacetophenones is presented. Functionalized arylmagnesium species are transmetalated to the corresponding arylzinc intermediates, which undergo Cu(I)-catalyzed reaction with acetoxyacetyl chloride. Acidic hydrolysis of the acetate group releases the target 伪-hydroxyacetophenones with minimal production of undesired polymeric degradates that are often observed under alternative conditions.